Antisense oligonucleotides as a targeted therapeutic approach in model of acute myeloid leukemia.

Background: The genetic and epigenetic alterations observed in acute myeloid leukemia (AML) contribute to its heterogeneity, influencing disease progression response to therapy, and patient outcomes. The use of antisense oligonucleotides (ASOs) technology allows for the design of oligonucleotide inhibitors based on gene sequence information alone, enabling precise targeting of key molecular pathways or specific genes implicated in AML.

Methods And Results: Midostaurin, a FLT3 specific inhibitor and ASOs targeting particular genes, exons, or mutations was conducted using AML models.

A new species of (Amphibia, Anura, Strabomantidae) from a montane forest of the Pui Pui Protected Forest in central Peru.

Herpetological inventories conducted in the Pui Pui Protected Forest in the central Peruvian Andes between 2012 and 2014 revealed unusually high local anuran richness and endemism. Herein, we describe a new species of discovered in the buffer zone of the protected area between 1550 and 1730 m a.s.

Influence of Strain Rate on Barkhausen Noise in Trip Steel.

This paper deals with Barkhausen noise in Trip steel RAK 40/70+Z1000MBO subjected to uniaxial plastic straining under variable strain rates. Barkhausen noise is investigated especially with respect to microstructure alterations expressed in terms of phase composition and dislocation density. The effects of sample heating and the corresponding Taylor-Quinney coefficient are considered as well.

Widespread Adaptive Introgression of Major Histocompatibility Complex Genes across Vertebrate Hybrid Zones.

Interspecific introgression is a potentially important source of novel variation of adaptive significance. Although multiple cases of adaptive introgression are well documented, broader generalizations about its targets and mechanisms are lacking. Multiallelic balancing selection, particularly when acting through rare allele advantage, is an evolutionary mechanism expected to favor adaptive introgression.

Taxonomic and nomenclatorial revision of the Neotropical genus Phaeoxantha Chaudoir (Coleoptera: Cicindelidae).

Taxonomic and nomenclatorial revision of the Neotropical tiger beetle genus Phaeoxantha Chaudoir, 1850 (originally Megacephala Latreille, 1802) is presented. Ammosia Westwood, 1852 (with type species Megacephala bifasciata) is confirmed as a junior synonym of Phaeoxantha. The results by Naviaux (2008), who rectified commonly confused taxonomy and nomenclature of Phaeoxantha nocturna (Dejean, 1831) and P.