Hypoxia-Responsive Polymersomes for Stemness Reduction in Patient-Derived Solid Tumor Spheroids.

Aggressive solid tumors are associated with rapid growth, early hypoxia, a lack of targeted therapies, and a poor prognosis. The hypoxic niches within the rapidly growing solid tumors give rise to a stem-cell-like phenotype with higher metastasis and drug resistance. To overcome the drug resistance of these regions, we used hypoxia-responsive polymersomes with an encapsulated anticancer drug (doxorubicin, Dox) and a stemness modulator (all-trans retinoic acid, ATRA).

Urinary Heparin Binding Protein: an Effective Marker in Assessing the Severity of UTI Compared to Microscopic Urinalysis.

Background: Proper and fast diagnosis of urinary tract infections (UTIs) is essential for suitable treatment strategy. Urine culture is the mainstay of diagnostic approaches, but it could be time consuming. Relying on clinical features alone may be misleading and may affect the precision of antibiotic regime.

Analysis of desert traffic accidents: A retrospective study.

Introduction: Motor vehicle accidents (MVAs) are a leading cause of mortality and morbidity worldwide. There is limited literature on the injuries resulting from desert off-road driving accidents. This study aims to delineate the attributes of desert MVA and associated injuries as observed in Qatar.

Adipsin and Leptin Levels in Type 2 Diabetic Patients on Sitagliptin and Metformin Versus Metformin Therapy.

Objectives: Adipsin and leptin are adipokines that link adipose tissue dysfunction and increased fat accumulation to obesity-related metabolic disorders. This study aimed to assess the effects of sitagliptin/metformin versus metformin monotherapy on the levels of adipsin, leptin, and lipid profile in type 2 diabetic patients.

Methods: This comparative case-control study included 120 participants divided into four groups: healthy participants, newly diagnosed type 2 diabetic patients, metformin-treated patients, and sitagliptin/metformin-treated patients.

Chemoprevention of natural product against oral cancer: A comprehensive review.

Introduction: Oral cancer is considered the sixth most common form of cancer worldwide. It causes significant morbidity and mortality, especially in low socioeconomic status groups. However, Cancer chemoprevention encompasses the use of specific compounds to suppress the growth of tumours or inhibit carcinogenesis.