Diversity in the medical research ecosystem: a descriptive scientometric analysis of over 49 000 studies and 150 000 authors published in high-impact medical journals between 2007 and 2022.

Objectives: Health research that significantly impacts global clinical practice and policy is often published in high-impact factor (IF) medical journals. These outlets play a pivotal role in the worldwide dissemination of novel medical knowledge. However, researchers identifying as women and those affiliated with institutions in low- and middle-income countries (LMICs) have been largely under-represented in high-IF journals across multiple fields of medicine.

Tactile, thermal and gustatory stimulation therapy in the treatment of post-stroke oropharyngeal dysphagia: a scoping review.

Purpose: To map in the literature the effects of tactile, thermal and/or gustatory stimulation on oropharyngeal dysphagia (OD) post-stroke.

Methods: This scoping review was conducted following the recommendations of PRISMA- ScR and the Joanna Briggs Institute (JBI), registered on the Open Science Framework and developed without language or publication period restrictions. Different databases and grey literature were used for article selection, and the PCC mnemonics constructed the research question ad eligibility criteria, thus including clinical studies involving adults (over 18 years old) diagnosed with OD post-stroke, who received tactile-thermal (TTS) and/or taste-gustatory (TGS) and/or tactile-thermal-gustatory stimulation for treatment, and had their effect measured through examinations, scales, or clinical assessment.

Techno-functionality of jack bean (Canavalia ensiformis) protein concentrate: a comparative study with soy and pea proteins.

Background: With the growing human awareness of the environmental and animal stress caused by the meat industry, the consumption of plant-based products has expanded. Plant proteins have gained market prominence due to their sustainable origin, economic value and health benefits. Well-established plant proteins in the market, such as those of soy and pea, have various applications as ingredients in the food industry.

Mechanistic basis for the emergence of EPS1 as a catalyst in salicylic acid biosynthesis of Brassicaceae.

Salicylic acid (SA) production in Brassicaceae plants is uniquely accelerated from isochorismate by EPS1, a newly identified enzyme in the BAHD acyltransferase family. We present crystal structures of EPS1 from Arabidopsis thaliana in both its apo and substrate-analog-bound forms. Integrating microsecond-scale molecular dynamics simulations with quantum mechanical cluster modeling, we propose a pericyclic rearrangement lyase mechanism for EPS1.

Analyzing how the components of the SOFA score change over time in their contribution to mortality.

Objective: Determine how each organ component of the SOFA score differs in its contribution to mortality risk and how that contribution may change over time.

Methods: We performed multivariate logistic regression analysis to assess the contribution of each organ component to mortality risk on Days 1 and 7 of an intensive care unit stay. We used data from two publicly available datasets, eICU Collaborative Research Database (eICU-CRD) (208 hospitals) and Medical Information Mart for Intensive Care IV (MIMIC-IV) (1 hospital).