Extension of sticholysins N-terminal α-helix signals membrane lipids to acquire curvature for toroidal pore formation.

Sticholysin I and II (St I/II) belong to the actinoporins family; these proteins form pores in host cell membranes by binding their N-terminal segment to the membrane, leading to protein-lipid (toroidal) pores. Peptides derived from actinoporins pore-forming domains replicate their folding properties and permeabilizing effects. Despite the advances in understanding how these proteins and peptides mediate pore formation, the role of different N-terminal segments in inducing membrane curvature is still unclear.

ROBOTIC PANCREATICODUODENECTOMY FOR THE TREATMENT OF A MIXED NEUROENDOCRINE-NON-NEUROENDOCRINE NEOPLASM (MINEN) OF THE AMPULLA OF VATER.

Mixed neuroendocrine-non-neuroendocrine tumors (MiNEN) are a rare type of tumor formed by two components, a non-neuroendocrine component that is most often an adenocarcinoma and a neuroendocrine tumor, and each of these components must represent at least 30% of the tumor. The origin of this tumor on the ampulla of Vater or periampullary region is more infrequent. Usually, the lesions are highly aggressive and quickly metastasizing, and their biological behavior is dictated by the high grade of the neuroendocrine component.

Assessing cost-effectiveness of dissuasion techniques targeting waterbirds in rice fields.

In a scenario of global wetland loss, rice fields are becoming vital habitats for waterbirds, often offering abundant and predictable food resources. However, the increasing presence of waterbirds in rice fields is exacerbating human-wildlife conflicts, as birds are seen as pests by farmers due to the damage they perceive the birds inflict to the crops. To tackle this situation, farmers use dissuasion methods like propane gas cannons, but its effectiveness in reducing damage is often not quantified.

Mutations in the main antigenic sites of VP7 and VP8* from G3P[8] rotavirus a strains circulating in Brazil may impact immune evasion to rotavirus vaccination.

In the post-rotavirus (RVA) vaccination era, uncommon and zoonotic strains have emerged as causative agents of acute gastroenteritis in humans, including the equine-like G3P[8] strains. First identified in 2013, this strain has quickly spread worldwide, reaching the position of the most prevalent genotype in many countries, including Brazil. Here, we report full genotype characterization and phylogenetic analysis of two equine-like G3P[8] strains detected in Goiás, a state in the Cerrado biome of the Brazilian Midwestern region, during the year of 2019.