Publications by authors named "J I Kresse"

Article Synopsis
  • Renal fibrosis is a key factor that worsens chronic kidney disease (CKD), resulting from excess extracellular matrix, and current treatments largely only target underlying conditions rather than the fibrosis itself.
  • This study investigates the use of preconditioned human adipose-derived mesenchymal stromal cells (Pr-MSCs) and their extracellular vesicles (EVs) for their anti-fibrotic potential, finding that local delivery of Pr-MSCs significantly reduced fibrosis markers and improved anti-inflammatory responses in kidney cells.
  • The results indicate that local administration of Pr-MSCs is more effective than systemic delivery, and the anti-fibrotic effects are likely due to soluble factors produced by Pr-MSCs, rather than the
View Article and Find Full Text PDF
Article Synopsis
  • Bimetallic nanostructures, such as Au-Pt aerogels, show great promise as enzyme-mimics, but understanding how their structure affects catalytic performance is challenging.
  • This study successfully creates three distinct structural configurations (segregated, alloy, core-shell) and finds that segregated structures significantly outperform the others in catalytic activity for peroxidase and glucose oxidase reactions.
  • The enhanced performance of segregated Au-Pt aerogels is due to their high-density interface boundaries, which allows for better substrate interaction and efficiency, potentially expanding their uses in biosensing and biological detection.
View Article and Find Full Text PDF

Alkaline water electrolysis holds promise for large-scale hydrogen production, yet it encounters challenges like high voltage and limited stability at higher current densities, primarily due to inefficient electron transport kinetics. Herein, a novel cobalt-based metallic heterostructure (CoMoN/CoN/Co) is designed for excellent water electrolysis. In operando Raman experiments reveal that the formation of the CoMoN/CoN heterointerface boosts the free water adsorption and dissociation, increasing the available protons for subsequent hydrogen production.

View Article and Find Full Text PDF

The physical properties of nanomaterials are determined by their structural features, making accurate structural control indispensable. This carries over to future applications. In the case of metal aerogels, highly porous networks of aggregated metal nanoparticles, such precise tuning is still largely pending.

View Article and Find Full Text PDF

Mesenchymal stromal/stem cell (MSC) therapy has been thoroughly tested in preclinical animal models and holds great promise for the treatment of kidney diseases. It is becoming increasingly evident that the efficacy of MSC therapy is dependent on several factors including dosage, the tissue source of MSCs, the route of delivery and timing of administration. In a time where MSC therapy is moving from preclinical research to clinically therapeutic use, the importance of choice of delivery method, modality, and administration route increases.

View Article and Find Full Text PDF