Publications by authors named "J I Hamada"

Article Synopsis
  • AMIGO2 is a protein that facilitates liver metastasis in tumor cells, and altering its expression impacts the cells’ ability to metastasize.
  • The study aimed to find ways to reduce liver metastasis by lowering AMIGO2 levels, testing 285 compounds and identifying five that effectively inhibit tumor cell adhesion to the liver.
  • Among these, the clinically available drug ruxolitinib was found to significantly reduce AMIGO2 expression and could effectively prevent liver metastasis in both mouse and human cancer cells.
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Article Synopsis
  • Researchers identified AMIGO2 as a key driver gene in liver metastasis and poor outcomes for colorectal cancer (CRC) patients.
  • The study explored how AMIGO2 promotes epithelial-mesenchymal transition (EMT), which enhances the invasion potential of CRC cells, primarily through the activation of the TGFβ/Smad signaling pathway.
  • Findings indicate that AMIGO2 is significantly expressed in the invasive front of tumors and its nuclear presence is linked to EMT marker expression, suggesting it could be targeted for therapies aiming to inhibit metastasis in CRC.
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Background: Behavioural parent training (BPT) is a psychosocial intervention designed for children with attention deficit hyperactivity disorder (ADHD). BPT programs teach parents to use effective commands or rules whilst encouraging them to pay careful attention to their child's appropriate behaviour. In this study, we will investigate the efficacy of BPT on parental stress, mothers' sense of emotional closeness to their children, and children's attachment security to their mothers.

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Wild-type transthyretin amyloid cardiomyopathy (ATTRwt-CM) is a progressive and infiltrative cardiac disorder that may cause fatal consequences if left untreated. The estimated survival time from diagnosis is approximately 3-6 years. Because of the non-specificity of initial symptom manifestation and insufficient awareness among treating physicians, approximately one-third of patients with ATTRwt-CM are initially misdiagnosed with other cardiac diseases.

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Background: Frozen shoulder (FS) is a common disorder causing shoulder pain and limited motion. Magnetic resonance imaging (MRI) is expected to help diagnose FS and realize the disease stage if stage-specific features are present. We aimed to survey stage-related MRI findings of FS in the literature.

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