Diterpenes: Nature's Hidden Gems of Immunomodulation.

Natural products, especially specific metabolites found in many medicinal plants, exhibit extensive therapeutic potential due to their diverse biological characteristics. Among these compounds, diterpenes stand out for their active principles described in phytochemical studies. Diterpenes exhibit immunomodulatory effects by influencing the production of cytokines and other signaling molecules involved in the immune response.

N-doped graphene quantum dots combined with Ag nanoparticles for luminescence based analytical sensing of gentamycin after solid-phase extraction in a molecularly-imprinted polymer.

A luminescence-based method was developed to detect gentamicin using silver nanoparticles (AgNPs) associated with nitrogen-doped graphene quantum dots (N-GQDs). When gentamicin sulfate interacts with the AgNPs/N-GQDs system, the characteristic blue fluorescence of N-GQDs, which had been previously turned off by AgNPs, is restored. Under specific conditions (such as the amount of synthesis dispersion and pH), this AgNPs/N-GQDs probe enabled quantification of gentamicin ranging from 3.

Variation in wood density across South American tropical forests.

Wood density is a critical control on tree biomass, so poor understanding of its spatial variation can lead to large and systematic errors in forest biomass estimates and carbon maps. The need to understand how and why wood density varies is especially critical in tropical America where forests have exceptional species diversity and spatial turnover in composition. As tree identity and forest composition are challenging to estimate remotely, ground surveys are essential to know the wood density of trees, whether measured directly or inferred from their identity.

Guttiferone E from Brazilian red propolis inhibited wound-isolated methicillin-resistant Staphylococcus aureus and enhanced the bactericidal action of suppressed macrophages.

Background: Propolis has been traditionally used to treat inflammatory and infectious diseases, and it is still used and researched worldwide. Methicillin-resistant Staphylococcus aureus (MRSA) may cause invasive infections and propolis anti-MRSA activity has been analyzed.

Purpose: A standardized red propolis extract (SRPE), its benzophenones-rich fraction (BRF), and isolated benzophenones (guttiferone E - GUT E, and oblongifolin B - OBL B) were assayed for their antibacterial and immunomodulatory action.

Effect of group-based nutritional education combined with individual standard care for outpatients with type 2 diabetes: study protocol for a randomized clinical trial {1}.

Background: Diabetes remains a significant contributor to global morbidity and mortality in the twenty-first century. Lifestyle modification strategies are widely recommended for effective diabetes management. Research suggests that a person-centered approach, implemented in either group or individual settings, offers considerable potential for improving long-term disease outcomes.