Body Image Dissatisfaction Is Increased in Inflammatory Bowel Disease Compared to Healthy Matched Controls but Not Diseased Controls: A Case-Control Study from New Zealand.

: Body image dissatisfaction is elevated in inflammatory bowel disease (IBD) as well as other chronic diseases. The aim of this study was to determine if the higher rate of body image dissatisfaction in IBD is specific to IBD or characteristic of chronic disease in general by comparing body image dissatisfaction in IBD patients with age- and gender-matched healthy individuals and those with type 1 diabetes mellitus (T1DM). : In this New Zealand-based case-control study conducted in a secondary care hospital, consecutive IBD patients aged 16 years and older were matched 1:1 with healthy individuals and T1DM patients based on age and gender.

Effects of early, late and self-selected time-restricted eating on visceral adipose tissue and cardiometabolic health in participants with overweight or obesity: a randomized controlled trial.

The optimal eating window for time-restricted eating (TRE) remains unclear, particularly its impact on visceral adipose tissue (VAT), which is associated with cardiometabolic morbidity and mortality. We investigated the effects of three TRE schedules (8 h windows in the early day, late day and participant-chosen times) combined with usual care (UC, based on education about the Mediterranean diet) versus UC alone over 12 weeks in adults with overweight or obesity. The primary outcome was VAT changes measured by magnetic resonance imaging.

Rapid and quantitative functional interrogation of human enhancer variant activity in live mice.

Functional analysis of non-coding variants associated with congenital disorders remains challenging due to the lack of efficient in vivo models. Here we introduce dual-enSERT, a robust Cas9-based two-color fluorescent reporter system which enables rapid, quantitative comparison of enhancer allele activities in live mice in less than two weeks. We use this technology to examine and measure the gain- and loss-of-function effects of enhancer variants previously linked to limb polydactyly, autism spectrum disorder, and craniofacial malformation.

Key concepts and a world-wide look at plant recruitment networks.

Plant-plant interactions are major determinants of the dynamics of terrestrial ecosystems. There is a long tradition in the study of these interactions, their mechanisms and their consequences using experimental, observational and theoretical approaches. Empirical studies overwhelmingly focus at the level of species pairs or small sets of species.

Sexual dimorphism on the acute effect of exercise in the morning vs. evening: A randomized crossover study.

Background: Mammalian cells possess molecular clocks, the adequate functioning of which is decisive for metabolic health. Exercise is known to modulate these clocks, potentially having distinct effects on metabolism depending on the time of day. This study aimed to investigate the impact of morning vs.