X-ray microtomography imaging enables accurate visualization and quantification of the small-intestinal villi microvasculature - celiac disease as a model.

Vasculature of the small bowel mucosa, with a significant role in nutrient absorption and gut homeostasis, has been suggested to undergo remodeling in various gastrointestinal disorders, including celiac disease. However, due to its spatial organization within the mucosa, conventional 2D histological methods are of limited value in studying the intestinal vasculature reliably. X-ray microtomography (micro-CT) is a promising tool for soft tissue imaging, as it enables digital 3D reconstruction of various tissue samples, including endoscopically obtained small-bowel mucosal biopsies.

Sensitivity-analysis-guided Bayesian parameter estimation for neural mass models: Applications in epilepsy.

It is well established that neural mass models (NMMs) can effectively simulate the mesoscopic and macroscopic dynamics of electroencephalography (EEG), including epileptic EEG. However, the use of NMMs to gain insight on the neuronal system by parameter estimation is hampered by their high dimensionality and the lack of knowledge on what NMM parameters can be reliably estimated. In this article, we analyze the parameter sensitivity of the Jansen and Rit NMM (JR NMM) in order to identify the most sensitive JR-NMM parameters for reliable parameter estimation from EEG data.

Micro-computed Tomography in the Evaluation of Eosin-stained Axillary Lymph Node Biopsies of Females Diagnosed with Breast Cancer.

Histopathological investigation of metastasis in core needle axillary lymph node (ALN) biopsies is crucial for the prognosis and treatment planning of breast cancer patients. Biopsies are typically sliced and evaluated as two-dimensional (2D) images. Biopsy sampling errors and the limited view provided by 2D histology are leading factors contributing to false-negative results in the preoperative detection of metastatic lymph nodes and underestimation of metastatic foci.

Oxidative Stress and Inflammation-Related mRNAs Are Elevated in Serum of a Finnish Wet AMD Cohort.

Purpose: Localized diseases can be affected by and affect the systemic environment via blood circulation. In this study, we explored the differences in circulating serum mRNAs between patients with wet AMD (wAMD) and controls.

Methods: Blood samples were obtained from 60 Finnish patients with wAMD and 64 controls.