Publications by authors named "J Humphrey"
Background: Few trials have explored long-term effects of interventions designed to reduce child stunting. We evaluated school-age outcomes in rural Zimbabwean children who received cluster-randomised water, sanitation and hygiene (WASH) and/or infant and young child feeding (IYCF) interventions from pregnancy up to 18 months of age.
Methods: The Sanitation Hygiene Infant Nutrition Efficacy (SHINE) trial enrolled pregnant women from two rural Zimbabwean districts (Chirumanzu and Shurugwi) between 2012 and 2015, and cluster-randomised them using a 2 × 2 factorial design to standard-of-care, WASH, IYCF, or combined WASH & IYCF, with a co-primary outcome of height-for-age Z-score and haemoglobin at 18 months (clinicaltrials.
Developing stable biopharmaceutical formulations is of paramount importance and is typically achieved by incorporating surfactants as stabilising agents, such as polysorbate 20 and 80. However, little is known about the effect surfactant grade has on formulation stability. This study evaluates the effect of regular grade and Super-refined™ polysorbates 20 and 80 and their interaction with model proteins, namely β-lactoglobulin (β-Ig), human serum albumin (HSA) and immunoglobulin gamma (IgG), using isothermal titration calorimetry (ITC) and differential scanning calorimetry (DSC).
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- - Alcohol-related mortality rates in the U.S. are rising, particularly among women, due to factors like local alcohol policies and community socioeconomic conditions, suggesting that these broader social determinants impact health outcomes.
- - A literature review conducted from March to May 2023 identified relevant studies from databases, focusing on area-level social determinants and their correlation with alcohol-related deaths while excluding non-peer-reviewed or irrelevant articles.
- - Out of 313 abstracts screened, 71 studies were selected for in-depth analysis, highlighting the importance of understanding these social factors to develop effective health interventions.
Background: Many prevention of vertical transmission (PVT) studies assess outcomes within 12 months postpartum and exclude those lost to follow-up (LTFU), potentially biasing outcomes toward those retained in care.
Setting: Five public facilities in western Kenya.
Methods: We recruited women living with HIV (WLH) ≥18 years enrolled in antenatal clinic (ANC).