Publications by authors named "J Humberto de Queiroz"
Real-world effectiveness of intravenous belimumab in adults with systemic lupus erythematosus: results of the observational OBSErve study in the Russian Federation.
BMC Rheumatol
January 2025
Background: The real-world effectiveness of intravenous (IV) belimumab in treating systemic lupus erythematosus (SLE) has been demonstrated in various countries through the OBSErve (evaluation Of use of Belimumab in clinical practice SEttings) program. Here we describe the clinical effectiveness of IV belimumab for treating SLE in real-world clinical practice in the Russian Federation.
Methods: In the retrospective, observational OBSErve Russia study (GSK Study 215349), eligible physicians enrolled adults with SLE receiving IV belimumab as part of their standard care.
Consumption of ultra-processed foods is associated with dietary iron availability, anemia, and excess weight in socially vulnerable children.
Clin Nutr ESPEN
February 2025
Background & Aims: Eating habits during childhood have undergone significant changes, with a notable increase in the consumption of ultra-processed foods (UPF). This situation deserves attention, given the close relationship between UPF and adverse health outcomes. This is due to the nutritional composition of UPF, which has high levels of health-critical nutrients such as sugar, fat, and sodium, thus compromising the overall quality of the diet.
View Article and Find Full Text PDFArticle Synopsis
- Infections from the dengue virus, Orthoflavivirus denguei, can show no symptoms or a range of clinical signs due to its complex interactions with viral and host factors.
- The study examined specific genetic variations (SNPs) in the interleukin-10 (IL-10) gene among 333 individuals in northeastern Brazil to see how they relate to symptomatic dengue.
- Findings revealed that certain genotypes and the G allele of the -1082 A/G SNP are associated with a higher risk of developing symptomatic dengue, particularly in contrast to those with asymptomatic infections.
Article Synopsis
- The Brazilian Amazon is a key area for hepatitis Delta virus (HDV) with hard-to-reach locations, making it crucial to study how the virus spreads there.
- A molecular analysis of HDV cases, involving 35 patients from Rondônia, Brazil, was conducted using PCR and sequencing to track the virus's evolution and transmission over time.
- Findings indicate that all samples were HDV-3, with an estimated entry into Brazil around 1820, suggesting complex migration patterns throughout the region over the past two centuries.*
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a high transmissibility profile which favors the accumulation of mutations along its genome, providing the emergence of new variants. In this context, haplotype studies have allowed mapping specific regions and combining approaches and tracking phylogenetic changes. During the COVID-19 pandemic, it was notorious that home environments favored the circulation of SARS-CoV-2, in this study we evaluated 1,407 individuals positive for SARS-CoV-2, in which we located 53 families in the period from June 2021 to February 2023.
View Article and Find Full Text PDF