Publications by authors named "J Huehn"
Epigenetic mechanisms stabilize gene expression patterns during CD8+ T cell differentiation. Although adoptive transfer of virus-specific T cells is clinically applied to reduce the risk of virus infection or reactivation in immunocompromised individuals, the DNA methylation pattern of virus-specific CD8+ T cells is largely unknown. Hence, we here performed whole-genome bisulfite sequencing of cytomegalovirus-specific human CD8+ T cells and found that they display a unique DNA methylation pattern consisting of 79 differentially methylated regions (DMRs) when compared to memory CD8+ T cells.
View Article and Find Full Text PDFThe number of older adults worldwide is growing exponentially. However, while living longer, older individuals are more susceptible to both non-infectious and infectious diseases, at least in part due to alterations of the immune system. Here, we report on a prospective cohort study investigating the influence of age on immune responses and susceptibility to infection.
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- * Researchers analyzed cytokine production before and after antibiotic treatment in over 1,000 patients, discovering a negative relationship between antibody production and IL-10 levels, as well as increased IL-1Ra in those with advanced disease.
- * Genome-wide mapping identified 34 cytokine quantitative trait loci (cQTLs), including 31 new ones, linking immune responses to Lyme borreliosis susceptibility and offering insights relevant to other immune-related diseases.
Article Synopsis
- Gut-draining mesenteric and celiac lymph nodes are essential for promoting tolerance to food and microbes by helping to generate regulatory T cells in the immune system.
- A brief gastrointestinal infection during infancy disrupts the ability of celiac lymph nodes to induce these protective Tregs by changing the characteristics of specific supporting cells within the lymph nodes.
- Lower levels of vitamin A after infection lead to lasting functional impairments in celiac lymph nodes, but early vitamin A treatment could mitigate these negative effects.