Publications by authors named "J Howlett"
Aims: Patients visiting the emergency department (ED) or hospitalized for heart failure (HF) are at increased risk for subsequent adverse outcomes, however effective risk stratification remains challenging. We utilized a machine-learning (ML)-based approach to identify HF patients at risk of adverse outcomes after an ED visit or hospitalization using a large regional administrative healthcare data system.
Methods And Results: Patients visiting the ED or hospitalized with HF between 2002-2016 in Alberta, Canada were included.
Article Synopsis
- Tafamidis is an expensive treatment for transthyretin amyloidosis cardiomyopathy (ATTR-CM) that shows positive outcomes, but predicting long-term effectiveness remains challenging.
- A study analyzed 139 ATTR-CM patients to identify baseline factors, such as age and renal function, linked to mortality and hospitalization, regardless of whether they received tafamidis.
- Key findings suggest that factors like renal function and frailty are critical indicators of adverse outcomes in ATTR-CM patients, which can help in better assessing treatment eligibility.
The multi-staged XENON program at INFN Laboratori Nazionali del Gran Sasso aims to detect dark matter with two-phase liquid xenon time projection chambers of increasing size and sensitivity. The XENONnT experiment is the latest detector in the program, planned to be an upgrade of its predecessor XENON1T. It features an active target of 5.
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