Oncologic Outcomes of Sequential Intravesical Gemcitabine and Docetaxel Compared with Bacillus Calmette-Guérin in Patients with Bacillus Calmette-Guérin-Unresponsive Non-Muscle Invasive Bladder Cancer.

Background And Objective: Non-muscle-invasive bladder cancer (NMIBC) patients treated with additional bacillus Calmette-Guérin (BCG) may become unresponsive to BCG. Recently, sequential intravesical gemcitabine and docetaxel (gem/doce) are being used for NMIBC. This study aims to compare oncologic outcomes between sequential intravesical gem/doce versus additional BCG in patients with BCG-unresponsive NMIBC.

Management, outcomes and predictors of mortality of Cryptococcus infection in patients without HIV: a multicentre study in 46 hospitals from Australia and New Zealand.

Background: Limited data exist regarding outcomes of cryptococcosis in patients without HIV with few studies having compared outcomes of Cryptococcus gattii, versus C. neoformans, infection.

Methods: We conducted a retrospective study in 46 Australian and New Zealand hospitals to determine the outcomes of cryptococcosis in patients without HIV diagnosed between 2015 and 2019, and compared outcomes of C.

A Conditional Indirect Effects Analysis of Intimate Partner Violence, Depression, Social Support, and Race With Alcohol Consumption among Postpartum Mothers.

Alcohol use and alcohol-related mortality for pregnant and postpartum women have increased, and there are racial disparities in both alcohol consumption and pregnancy outcomes. In addition, data indicate that women of Color are more likely to experience many forms of violence and face more adverse consequences from violence than non-Hispanic White women. Therefore, the current study examined how the direct and indirect pathways between intimate partner violence (IPV), depressive symptoms, and alcohol consumption are moderated by both social support and race among postpartum women.

Evidence of a Catalytic Dyad in F-Dependent Glucose-6-phosphate Dehydrogenase from .

F-dependent glucose-6-phosphate dehydrogenase (FGD) catalyzes the conversion of glucose-6-phosphate (G6P) to 6-phosphogluconolactone, using cofactor F as the hydride transfer acceptor. Our previous pH dependence studies suggested that E109 serves as an active site acid, donating a proton to the N-1 position of F, while leaving the role of H40 unanswered, which was previously suggested to serve as the active site base. This work utilizes thermodynamic and kinetic studies to elucidate additional mechanistic details concerning the roles of H40 and E13.

Molecular Detection of Shiga Toxin-Producing O177 Isolates, Their Antibiotic Resistance, and Virulence Profiles From Broiler Chickens.

The World Health Organization (WHO) describes Shiga toxin-producing (STEC) as a bacterium that can cause severe food-borne diseases. Common sources of infection include undercooked meat products and faecal contamination in vegetables. This study aimed to isolate, identify and assess the virulence and antibiotic resistance profiles of STEC isolates from broiler chicken faeces.