Publications by authors named "J Horodnicki"

Aim: The aim of this work was to investigate differences in parents' personality and dopaminergic and serotoninergic gene polymorphisms which may affect certain predispositions to alcohol dependence as described in the typology developed by R. Cloninger and O.M.

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Article Synopsis
  • - The paper examines genetic polymorphisms related to alcoholism, specifically focusing on variations in the dopaminergic system and how they predispose individuals to severe alcoholism, particularly in a sample of 100 Polish families with alcohol dependence.
  • - The study employed the transmission disequilibrium test (TDT) and found significant differences in allele transmission for certain gene polymorphisms (DRD2 TaqIA and DAT) among early onset alcoholics, while no substantial differences were noted between alcoholics and healthy controls in overall alleles and genotype distribution.
  • - The findings suggest that candidate genes like DRD2 and DAT contribute to alcohol dependence and indicate a genetic basis for different subtypes of alcoholism, highlighting the complexity of treating alcohol dependence
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Occurrence of anxiety and depression was investigated in 76 patients with recognized larynx and/or hypopharynx cancer and with or without alcohol dependence. The patients were treated using total or partial laryngectomy or radiotherapy. Patients were examined three times using questionnaires: SCID, BDI, STAI.

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The aim of this study was to evaluate the role of the GRIK3 functional polymorphism (Ser310Ala) in the pathogenesis of alcoholism. This polymorphism was investigated in two types of studies: (1) the association study in a whole group of alcoholics (116 patients fulfilling ICD-10 alcohol dependence (AD) criteria and 255 controls, Polish descent) and homogenous overlapping subgroups of patients with: a history of delirium tremens and/or alcohol seizures, early age of onset of alcoholism (AOO<26 years), a co-occurrence of dissocial personality disorder, a history of familial alcoholism; (2) the family-based study (using Transmission Disequilibrium Test (TDT) in 100 Polish families with alcohol dependence). The history of alcoholism was obtained using SSAGA (Polish version).

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In this research psychic and somatic symptoms related to disturbances of hypothalamus-hypophysis-peripheral regulation which may occur in the schizophrenic process were analysed. Authors discussed the problem of relations between hypothalamus neuroregulation and pathogenesis of endocrine disturbances which suggest the organic cause of obesity, hirsutism and secondary amenorrhea among women diagnosed with paranoid schizophrenia. Actual antipsychotic pharmacological treatment, including some side-effects: the metabolic (obesity) and the endocrine (hyperprolactinemia) ones were considered.

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