Publications by authors named "J Holtzmann"
Objectives: Electroconvulsive therapy (ECT) is one of the most effective treatments in mood disorders, mainly in major depressive episode (MDE) in the context of either unipolar (MDD) or bipolar disorder (BD). However, ECT remains a neglected and underused treatment. Older people are at high risk patients for the development of adverse drug reactions.
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- Previous research indicates that individuals with treatment-resistant depression (TRD) experience significant cognitive impairments, but the progression of these impairments based on treatment response has been understudied.
- The study analyzed 131 TRD patients over a year to compare cognitive performance changes in those who responded to treatment versus those who did not.
- Findings showed persistent cognitive impairments in both groups, but responders exhibited more significant improvements, suggesting the need for cognitive remediation to enhance their daily functioning post-treatment.
Long-term benzodiazepine prescription in treatment-resistant depression: A national FACE-TRD prospective study.
Prog Neuropsychopharmacol Biol Psychiatry
August 2023
Background: Benzodiazepine long-term use (BLTU) is a public health challenge. We lack data on the consequences of LBTU on the trajectory of treatment-resistant depression (TRD).
Objective: To determine the prevalence of BLTU in a nationwide non-selected population of patients with TRD, to determine the rate of patients succeeding at withdrawing benzodiazepines at one year and to determine if persistent BLTU is associated with poorer mental health outcomes.