[Effect of fluvastatin on serum lipid levels in essential hypertension].

The efficacy and safety of the HMG-CoA reductase fluvastatin was investigated in a multicenter, open label clinical therapeutic trial in the treatment of hypercholesterinaemia in hypertensive patients (WHO I-II.). 49 patients were involved, 6 patients were dropped out because of th lack of compliance, 43 patients were investigated (mean age: 57.

Interaction of taxol and other anticancer drugs with alpha-cyclodextrin.

The interaction between 23 anticancer drugs and alpha-cyclodextrin (alpha-CD) was studied by reversed-phase charge-transfer thin-layer chromatography and the relative strength of interaction was calculated. As alpha-CD has smaller cavity than beta- and tau-CD it interacted only with 10 anticancer drugs proving the relatively poor complex forming capacity of alpha-CD. The hydrophobicity of host-guest inclusion complex was always different from that of the uncomplexed drug suggesting that the complex formation may influence the uptake, absorption, half-life etc.

Hungarian Isradipine Study (HIS): long-term (3-year) effects on blood pressure and plasma lipids.

These are the preliminary data of an open multicenter trial of antihypertensive treatment with isradipine as monotherapy (dose, 4.55 +/- 0.56 mg twice daily; n = 11) or isradipine (7.