Publications by authors named "J Holle"

Introduction: Poor quality sleep has often been cited as a cause of lowered quality of life in patients with affective disorders such as major depressive disorder (MDD) and generalized anxiety disorder (GAD). As sleep and affective disorders are affected by multi-network interactions, we hypothesize that the modulation of the central executive network (CEN), salience, and default mode networks (DMNs) through individualized repetitive transcranial magnetic stimulation (rTMS) may improve sleep and quality of life.

Methods: A retrospective analysis from 2020 to 2023 was conducted in patients with affective disorders at Cingulum Health.

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Pain in the musculoskeletal system and therefore joint pain is one of the most common reasons for consulting a general practitioner (GP). Inflammatory rheumatic diseases are among the important differential diagnoses. However, the prevalence of rheumatological diseases is significantly lower than that of degenerative causes of pain.

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Introduction: Over the last decade, the number of patients receiving home mechanical ventilation (HMV) has increased significantly, which has led to a limited availability of specialist centres, not least due to the scarcity of healthcare professionals. This situation was exacerbated by the COVID-19 pandemic. It is therefore assumed that the repurposing of resources has led to an aggravated change in the healthcare structure in HMV.

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Article Synopsis
  • - This article reviews updated treatment guidelines for Anti-Neutrophil Cytoplasmic Antibody (ANCA)-associated vasculitis (AAV) from major organizations including EULAR, KDIGO, and ACR, highlighting the role of glucocorticoids and biologics.
  • - Rituximab (RTX) is recommended for managing granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA), while anti-IL5 strategies are used for eosinophilic GPA (EGPA) in conjunction with glucocorticoids for non-organ-threatening cases.
  • - The article notes a trend towards lower doses of glucocorticoids and introduces avacopan as a
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