Publications by authors named "J Hoheisel"
Article Synopsis
- Early and aggressive metastasis is a defining characteristic of pancreatic ductal adenocarcinoma, making it important to understand the genes involved in this process to improve disease outcomes.
- Researchers performed a genome-wide CRISPR-Cas9 knockout screen on pancreatic cancer cell lines with different metastatic capacities to identify metastasis-specific genes and analyzed their functions through in vitro experiments and in vivo mouse models.
- The study found that knocking out 590 genes significantly impacted the viability of metastatic cells, revealing new insights into the molecular processes involved in metastasis and highlighting the need for further investigation into these critical genes and their interactions.
Pancreatic ductal adenocarcinoma (PDAC) comprises two clinically relevant molecular subtypes that are currently determined using tissue biopsies, which are spatially biased and highly invasive. We used whole transcriptome sequencing of 10 plasma samples with tumor-informed subtypes, complemented by proteomic analysis for minimally invasive identification of PDAC subtype markers. Data were validated in independent large cohorts and correlated with treatment response and patient outcome.
View Article and Find Full Text PDFA systemic look at pancreatic cancer patients: Predicting metastasis by studying the liver.
Signal Transduct Target Ther
September 2024
Article Synopsis
- Extracellular vesicles (EVs), particularly melanosomes secreted by melanocytes, are revealed as key players in intercellular communication, allowing intact transfer of melanin between cells.
- These melanosomes gain distinct protein signatures within receiving cells and can be further passed to other cells, like macrophages, influencing their polarization towards either pro-tumor or immune cell types.
- In melanoma, the presence of specific melanosome markers in macrophages correlates with disease aggressiveness and highlights the potential of targeting melanosome interactions to hinder melanoma progression.
Objective: Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy. Differentiation from chronic pancreatitis (CP) is currently inaccurate in about one-third of cases. Misdiagnoses in both directions, however, have severe consequences for patients.
View Article and Find Full Text PDF