Complex Alterations of Fatty Acid Metabolism and Phospholipidome Uncovered in Isolated Colon Cancer Epithelial Cells.

The development of colon cancer, one of the most common malignancies, is accompanied with numerous lipid alterations. However, analyses of whole tumor samples may not always provide an accurate description of specific changes occurring directly in tumor epithelial cells. Here, we analyzed in detail the phospholipid (PL), lysophospholipid (lysoPL), and fatty acid (FA) profiles of purified EpCAM cells, isolated from tumor and adjacent non-tumor tissues of colon cancer patients.

Tribology provides an in vitro tool that correlated to in vivo sensory data on the mouthfeel of coated tablets.

Tribology is an emerging technique in the pharmaceutical field for texture and mouthfeel studies. Due to its relevance to oral sensory perception, tribology supports the development of novel products in the food industry. This study explores tribology as a tool to optimise the mouthfeel and ease of swallowing of pharmaceutical coatings and coated tablets.

A review of in vitro and in vivo methods and their correlations to assess mouthfeel of solid oral dosage forms.

This review analyses the relationship between instrumental and human data used to assess the mouthfeel of solid oral dosage forms to provide recommendations on the most appropriate methods to use in future studies.

Sensory attributes of coated tablets: Developing a formal lexicon and sensory wheel.

The patient's sensory experience when taking an oral medicine is important in the assessment of its palatability, and acceptability. The aim of this study was to develop tools useful for standardisation of sensory assessment of coated tablets: a lexicon and a sensory wheel. Two randomised, double-blind sensory assessments were performed involving 83 and 52 heathy adult volunteers and two sets of coated tablets.