Publications by authors named "J Hofmann"
Background: Occupational exposure to endotoxin has been associated with reduced lung cancer risk. The mechanisms underlying this association are unclear, though immunological alterations likely play a role. Farmers who perform certain tasks (eg, raising hogs) can be highly exposed to endotoxin.
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- A study examined the link between pesticide use and the risk of rheumatoid arthritis (RA) among licensed pesticide applicators, primarily white male farmers in North Carolina and Iowa, observing data from 1993 to 2016.
- Out of over 22,000 applicators aged 67 and older, 161 developed RA after not having claims for at least a year, with nine specific pesticides showing increased risk.
- Notable pesticides associated with elevated RA risk include malathion, carbaryl, and various herbicides and fungicides, indicating a potential health concern for older adults exposed to these chemicals.
Objective: Elevated pesticide concentrations have been found in dust from homes with residents who use agricultural pesticides, but few studies have compared these concentrations to quantitative measures of their use. We evaluated household pesticide dust concentrations in relation to quantitative, active ingredient-specific metrics of agricultural pesticide use in the Biomarkers of Exposure and Effect in Agriculture Study.
Methods: Participants provided vacuum dust samples (2013-2018) and information regarding recent (last 12 months) and lifetime pesticide use.
Introduction: Dysregulated androgen receptor (AR) activity is central to various diseases, particularly prostate cancer (PCa), in which it drives tumour initiation and progression. Consequently, antagonising AR activity via anti-androgens is an indispensable treatment option for metastatic PCa. However, despite initial tumour remission, drug resistance occurs.
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