Unbiased chemokine receptor screening reveals similar efficacy of lymph node- and tumor-targeted T cell immunotherapy.

Localization is a crucial prerequisite for immune cell function and solid tumors evade immune control by modulating immune cell infiltration into the tumor stroma. Immunosuppressive cells like regulatory T cells are attracted, while cytotoxic CD8 T cells are excluded. Engineering CD8 T cells with chemokine receptors is a potent strategy to turn this mechanism of directed immune cell recruitment against the tumor.

A floating-point digital receiver for MRI.

A magnetic resonance imaging (MRI) system requires the highest possible signal fidelity and stability for clinical applications. Quadrature analog receivers have problems with channel matching, dc offset and analog-to-digital linearity. Fixed-point digital receivers (DRs) reduce all of these problems.

Echo-planar pediatric imager.

Practical constraints make it difficult to build large-aperture echo-planar magnetic resonance (MR) imagers. The implementation of a pediatric imager and its performance are described. Spatial resolution and signal-to-noise levels comparable to those of 1982 state-of-the-art MR imagers have been achieved in imaging times of 0.

Contiguous thin multisection MR imaging by two-dimensional Fourier transform techniques.

Section thickness in two-dimensional Fourier transform (FT) imaging is dependent on gradient strength and the shape of the radio-frequency pulses used to excite the nuclei. By manipulation of these parameters, it is possible to obtain 2.5-mm-thick sections in contiguous, multisection imaging.