Publications by authors named "J Hochberger"

Background And Aims: Esophageal stricture (ES) is a severe adverse event following wide-field endoscopic submucosal dissection (ESD) of superficial esophageal carcinoma. This study evaluated the efficacy and safety of combining endoscopic vacuum therapy (EVT) and budesonide orodispersible tablet (BOT) in preventing post-ESD strictures.

Methods: This prospective case series included patients with superficial esophageal squamous cell carcinoma and adenocarcinoma who had wide-field ESD (≥75% circumference, resection length ≥50 mm).

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Today, endoscopy plays a decisive role not only in the detection of colorectal adenomas and carcinomas, but also in the treatment of precancerous lesions, in particular flat adenomas and early carcinomas. In recent years, endoscopic submucosal dissection (ESD) has become increasingly important alongside classic polypectomy and mucosal resection after saline injection using a snare (EMR). Using ESD the lesion is marked, injected submucosally using viscous substances and the mucosa incised and tunneled with a transparent cap and a fine diathermy knife.

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Background: Delayed bleeding is the most frequent complication after endoscopic submucosal dissection (ESD) and endoscopic mucosal resection (EMR) of large colon polyps. Today, prophylactic clipping with through-the-scope clips (TTSCs) is commonly used to reduce the risk of bleeding. However, the over-the-scope clip (OTSC) system might be superior to TTSCs in achieving hemostasis.

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Article Synopsis
  • OTSCs (over-the-scope clips) enhance the treatment of severe gastrointestinal bleeding and may outperform standard clips, but the effectiveness of different OTSC designs (traumatic vs. atraumatic) for duodenal ulcer bleeding hasn't been previously studied.
  • A study analyzed data from 6 German centers over 11 years, involving 173 patients with duodenal ulcer bleeding treated with OTSCs, comparing outcomes between the two types.
  • Results indicated no significant difference in initial hemostasis or mortality; however, the traumatic OTSCs led to a much higher rate of recurrent bleeding and greater need for blood transfusions, suggesting atraumatic OTSCs are the better option for treatment.
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Objectives: Endoscopic trans-anal colonic decompression (ECD) may be requested in the case of massive colon distension, but evidence regarding success and safety issues remains scarce. The aim of this analysis is to examine the technical success, complications and clinical outcome in a large series of patients undergoing an ECD in various clinical scenarios. A standardized evaluation system was used to identify the pre-interventional risk parameters that might be helpful to guide clinical decision making.

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