Publications by authors named "J Hlubocky"
Background: Venotonics are a class of therapeutically active molecules that have vaso-protective effects. They are used to alleviate venous diseases and disorders, particularly venous insufficiency. We compared the composition of prescription versus over-the-counter (OTC) venotonics using high-performance liquid chromatography with UV detection (HPLC-DAD) and simulating their digestion using a static digestive model.
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- The study aimed to compare two techniques for valve-sparing root replacement in patients with aortic root aneurysm: aortic root remodelling and aortic valve reimplantation, utilizing a multicenter approach and propensity-score matching.* -
- Researchers conducted a retrospective analysis of data from 2010 to 2021, selecting pairs of patients who underwent either technique to evaluate perioperative outcomes and long-term valve function.* -
- Findings indicated that while there were no significant differences in short-term outcomes, patients who underwent remodelling faced a higher risk of needing further interventions compared to those who had reimplantation, especially if immediate postoperative valve function was suboptimal.*
Background: Use of the current echocardiography-based indications for aortic regurgitation (AR) surgery might result in late valve replacement at the stage of irreversible myocardial damage. Therefore, we aimed to identify simple models combining multiple echocardiography or magnetic resonance imaging (MRI)-derived indices and natriuretic peptides (BNP [brain natriuretic peptide] or NT-proBNP [N-terminnal pro-B type natriuretic peptide]) to predict early disease decompensation in asymptomatic severe AR.
Methods: This prospective and multicenter study included asymptomatic patients with severe AR, preserved left ventricular ejection fraction (>50%), and sinus rhythm.
Background: Unicuspid aortic valve (UAV) is the second most common underlying cause of aortic valve dysfunction in young adults after the bicuspid valve. The valve may be replaced (for example by pulmonary autograft) or repaired using the bicuspidization technique. The aim of our study was to compare short- and mid-term outcomes of Ross procedure with bicuspidization in patients with severe UAV dysfunction.
View Article and Find Full Text PDFReliable quantification of aortic regurgitation (AR) severity is essential for clinical management. We aimed to compare quantitative and indirect echo-Doppler indices to quantitative cardiac magnetic resonance (CMR) parameters in asymptomatic chronic severe AR. Methods and Results: We evaluated 104 consecutive patients using echocardiography and CMR.
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