YgiV promoter mutations cause resistance to cystobactamids and reduced virulence factor expression in Escherichia coli.

Antimicrobial resistance is one of the major health threats of the modern world. Thus, new structural classes of antimicrobial compounds are needed in order to overcome existing resistance. Cystobactamids represent one such new compound class that inhibit the well-established target bacterial type II topoisomerases while exhibiting superior antibacterial and resistance-breaking properties.

European core curriculum--the students' perspective, Bristol, UK, 10 July 2006.

The International Federation of Medical Students' Associations (IFMSA) and the European Medical Students' Association (EMSA) are proud to present the first outcome-based core curriculum for medicine from the perspective of the medical students of Europe. It covers 76 learning outcomes grouped around nine domains: (1) Clinical Skills, (2) Communication, (3) Critical Thinking, (4) Health in Society, (5) Lifelong Learning, (6) Professionalism-Attitudes, Responsibilities, and Self-development, (7) Teaching, (8) Teamwork, and (9) Theoretical knowledge. The statement is a result of a long process of international workshops, conferences, and discussions on numerous meetings for medical students and health-care professionals all over Europe.

[Ultrasound guided implantation of chest port systems via the lateral subclavian vein].

Purpose: Retrospective analysis of the success and complication rates of chest port implantation via the lateral subclavian vein.

Materials And Methods: Between January 2003 and June 2004, the lateral subclavian vein in 271 patients (186 women, 85 men, mean age 53.2 years) was punctured guided by ultrasound.