The abnormal development of male sex organs in the rat using a pure antiandrogen and a 5 alpha-reductase inhibitor during gestation.

The effects of a pure antiandrogen flutamide and the 5 alpha-reductase inhibitor finestaride on both prenatal differentiation of prostate and external genitalia were studied in the rat. In control male offspring the mean value of anogenital distance was 3.1 +/- 0.

Effects of castration, androgen replacement and flutamide treatment on the contractile function of the rat prostate.

The contractile activity of the rat prostate was registered in vivo by means of a video recording system. An increase in tone was registered in control animals after electrical stimulations were applied to hypogastric ganglion. Similar result was obtained after norepinephrine or acetylcholine administration.

The in vivo effects of autonomic drugs and electroejaculation on prostate gland contractility in the rat.

The effects of various autonomic drugs and electroejaculation on the contractile activity of the rat prostate were registered in vivo by means of a video recording system. The changes in the glandular tone were measured by observing the modification of distance between two superficial paralel blood vessels used as references. Norepinephrine, epinephrine, acetylcholine and electrical stimulations produced an increase in the ronus.

Changes in the contractile activity of the male genital tract as a consequence of vasectomy.

The contractile activity of the cauda epididymidis and vas deferens was registered in the rat under a video camera at intervals up to 180 days after vasectomy. A rhythmic peristaltic activity was detected as early as 24 hours after operation, specially in the distal cauda epididymidis. The contractions increased progressively during the first 30 days after vasectomies.

Contractile behaviour of rat seminal vesicle after gonadectomy, testosterone replacement and cyproterone treatment.

The effects of bilateral gonadectomy, testosterone replacement and cyproterone acetate treatment on seminal vesicle contractions were studied in rats in order to contribute new data on the role of androgens in the spontaneous motility of the seminal vesicle. In gonadectomized-testosterone treated rats the glands exhibited a spontaneous rhythmic activity similar to that of entire animals. The seminal vesicles of gonadectomized as well as of cyproterone treated rats also contracted spontaneously but the contractions showed a smaller amplitude.