Publications by authors named "J Herz"
Low-density lipoprotein receptor-related protein-1 (LRP1) is thought to be correlated with hepatocellular carcinoma (HCC) invasion and metastasis. However, the precise mechanism through which LRP1 contributes to HCC progression remains unclear. Here, lower LRP1 levels are associated with malignant progression, and poor prognosis in patients with HCC is shown.
View Article and Find Full Text PDFImportance: The X chromosome has remained enigmatic in Alzheimer disease (AD), yet it makes up 5% of the genome and carries a high proportion of genes expressed in the brain, making it particularly appealing as a potential source of unexplored genetic variation in AD.
Objectives: To perform the first large-scale X chromosome-wide association study (XWAS) of AD.
Design, Setting, And Participants: This was a meta-analysis of genetic association studies in case-control, family-based, population-based, and longitudinal AD-related cohorts from the US Alzheimer's Disease Genetics Consortium, the Alzheimer's Disease Sequencing Project, the UK Biobank, the Finnish health registry, and the US Million Veterans Program.
Article Synopsis
- - Heterozygous mutations in the GRN gene are a key cause of hereditary frontotemporal dementia, but the underlying mechanisms and treatments are not well understood.
- - The proposed strategy involves using small molecules to enhance GRN expression from the remaining good GRN allele, aiming to normalize progranulin levels in the brain.
- - Research identifies new small molecules that effectively increase progranulin levels in human cells and Grn mouse brains, potentially reversing symptoms associated with frontotemporal dementia and paving the way for future drug development.