Regulation of Safracin Biosynthesis and Transport in PMA22.

PMA22 produces safracins, a family of compounds with potent broad-spectrum anti-bacterial and anti-tumor activities. The safracins' biosynthetic gene cluster (BGC sac) consists of 11 ORFs organized in two divergent operons ( and ) that are controlled by and promoters. Contiguous to the BGC sac, we have located a gene that encodes a putative global regulator of the LysR family annotated as MexT that was originally described as a transcriptional activator of the MexEF-OprN multidrug efflux pump in .

[Pediatric knee arthroscopy. Three-year experience at a high specialty hospital in Mexico].

Introduction: Diagnosis and management of congenital and traumatic articular ailments carry an additional problem in young people. Arthroscopy has improved treatment of these injuries, which are more frequent.

Objective: To describe the experience of arthroscopic handling in pediatric patients affected with knee disease, managed at a third level hospital in Puebla, Mexico.

[Mucocutaneous lymph node syndrome (Kawasaki disease). Presentation of 3 cases].

Authors report three cases of Kawasaki disease who were admitted to hospital during the period of November 1981 and January 1982. Two of these patients had an excellent evolution while the third one died in the second stage of the disease due to an anterior-external and septal myocordial infarction. They could not find etiological factors nor could establish a relationship to histocompatibility antigen.