Application of rapid, electrochemical Flash Titration to total acidity and alkalinity determinations in buffers, foods, and beverages.

A new technique (Flash Titration) for the determination of total acidity and total alkalinity was applied to food and beverage analysis. Requiring no liquid titrants, Flash Titration is a technique made possible through microfabrication of electrochemical components on a silicon chip. Acidic or basic titrant was generated electrochemically at a noble-metal electrode that intimately surrounded an ion-selective, field-effect transistor pH sensor.

In vitro inhibition of DNA adduct formation by hindered hydroquinols and quinones.

A series of thirty-one chemicals (substituted phenols, hydroquinols, quinones and quinoneimines) were investigated as in vitro inhibitors of DNA-benzo[a]pyrene adducts formation. In order to establish the mechanisms by which such compounds may elicit a protective effect at DNA level, the influence of these compounds upon benzo[a]pyrene (BaP) activation by 3-methyl-cholanthrene-stimulated microsomes was also studied. The data obtained suggest that the tested compounds act mainly (but not only) by BaP metabolism inhibition.

A new class of potential carcinogenesis inhibitors: hindered p-benzoquinones.

The investigation of the mechanisms of action by which phenolic antioxidants (i.e. BHA, BHT, etc.