Publications by authors named "J Hercogova"
Article Synopsis
- * Infliximab was associated with higher rates of liver issues, fatigue, and infections, while adalimumab led to more musculoskeletal disorders and infections. Secukinumab patients showed more cardiovascular problems, and etanercept was linked to menstrual disorders.
- * Ustekinumab had the safest profile among the treatments, suggesting that individual risk profiles should be evaluated before starting biologic therapies, and further research is needed to confirm these findings.
Atopic dermatitis is a chronic skin condition for which a range of systemic treatments have recently been approved. A treat-to-target strategy has been developed previously alongside an algorithm to guide the management of patients with atopic dermatitis. Here, we review the strategy and algorithm in the context of the evolving therapeutic landscape, and identify areas for further refinement and development.
View Article and Find Full Text PDFBackground: Ustekinumab, is a new therapy for patients with IBD, especially for patients suffering from Crohn's disease (CD) who did not respond to anti-TNF treatment. To shed light on the longitudinal effect of ustekinumab on the immune system, we investigated the effect on skin and gut microbiota composition, specific immune response to commensals, and various serum biomarkers.
Methodology/principal Findings: We recruited 11 patients with IBD who were monitored over 40 weeks of ustekinumab therapy and 39 healthy controls (HC).
Article Synopsis
- HIV-positive men who have sex with men (MSM) in the Czech Republic show high rates of anal HPV infection (96.8%) and lower rates of oral HPV infection (23.6%), with HPV16 being the most common type found in anal samples.
- The study analyzed samples from 205 HIV-positive MSM using PCR testing and examined correlations between HPV detection and various clinical factors through advanced statistical methods.
- Findings indicate a significant relationship between multiple anal HPV infections, the presence of vaccine-targeted HPV types, and the risk of abnormalities in anal cytology, highlighting a concerning prevalence of HPV in this population.
Inflammatory bowel diseases (IBD) are chronic disorders of the gastrointestinal tract that have been linked to microbiome dysbiosis and immune system dysregulation. We investigated the longitudinal effect of anti-TNF therapy on gut microbiota composition and specific immune response to commensals in IBD patients. The study included 52 patients tracked over 38 weeks of therapy and 37 healthy controls (HC).
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