Publications by authors named "J Heppell"

Article Synopsis
  • New drugs for treating visceral leishmaniasis are urgently needed, but there haven't been many suitable candidates developed recently.
  • DNDI-6174 is a promising new compound derived from a specific chemical series that shows strong potential against various species of the parasite causing the disease.
  • Preliminary studies on DNDI-6174 indicate it has good safety and effectiveness, making it a viable option for further preclinical development.
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The growth of rice in submerged soils depends on its ability to form continuous gas channels-aerenchyma-through which oxygen (O ) diffuses from the shoots to aerate the roots. Less well understood is the extent to which aerenchyma permits venting of respiratory carbon dioxide (CO ) in the opposite direction. Large, potentially toxic concentrations of dissolved CO develop in submerged rice soils.

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This study documented the 6-month incidence of panic disorder and its predictors in emergency department patients with panic attacks and non-cardiac chest pain. The assessment included a validated structured interview to identify panic attacks and questionnaires measuring the potential predictors of panic disorder. Presence of panic disorder was assessed 6 months later.

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Background And Aim: Recycled sources of phosphorus (P), such as struvite extracted from wastewater, have potential to substitute for more soluble manufactured fertilisers and help reduce the long-term threat to food security from dwindling finite reserves of phosphate rock (PR). This study aimed to determine whether struvite could be a component of a sustainable P fertiliser management strategy for arable crops.

Methods: A combination of laboratory experiments, pot trials and mathematical modelling of the root system examined the P release properties of commercial fertiliser-grade struvite and patterns of P uptake from a low-P sandy soil by two different crop types, in comparison to more soluble inorganic P fertilisers (di-ammonium phosphate (DAP) and triple super phosphate (TSP)).

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The lymphatic system returns fluid to the bloodstream from the tissues to maintain tissue fluid homeostasis. Lymph nodes distributed throughout the system filter the lymphatic fluid. The afferent and efferent lymph flow conditions of lymph nodes can be measured in experiments; however, it is difficult to measure the flow within the nodes.

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