Modulating role of glucose on magnesium transport in rat erythrocytes.

Magnesium efflux from rat erythrocytes has been shown to be inhibited by a plasma fraction containing glucose. Therefore, we investigated the effect of D-glucose on erythrocyte magnesium transport. We show the inhibitory activity of this hexose on sodium (Na(+))-independent erythrocyte magnesium (Mg(2+)E) efflux.

Magnesium metabolism in mice selected for high and low erythrocyte magnesium levels.

A genetic control of blood magnesium (Mg) levels has been suggested. To investigate the mechanisms and the biologic significance of this genetic regulation, a mouse model, ie, mice selected for low magnesium level (MGL) and high magnesium level (MGH), was developed. The purpose of this study was to explore the Mg status and Mg metabolism in female MGL and MGH mice.

Magnesium involvement in sleep: genetic and nutritional models.

Alterations of peripheral magnesium (Mg) concentration have been reported in association with several behavioral disorders and sleep organization. Blood Mg regulation is under a strong genetic control, whereas brain Mg regulation does not seem to be affected. We have studied peripheral and central levels of Mg and analyzed sleep in two lines of mice selected for low (MGL) and high (MGH) red blood cell (RBC) Mg levels.

Unexpected association between reproductive longevity and blood magnesium levels in a new model of selected mouse strains.

Two recently described mouse strains, with high (MGH) and low (MGL) blood magnesium (Mg) levels were obtained by selection over 19 generations. Both strains exhibit strong differences for characteristics generally known to be related to blood Mg levels, such as increased stress sensitivity and stress-induced aggressivity in MGL mice. In contrast, while experimental Mg deficiency due to low oral Mg intake has been shown to shorten life span and lower reproductive ability, reproductive longevity was longer in the MGL than in the MGH strain.

[Not Available].

In previous reports, we have observed that blood magnesium was significantly higher in drug-free patients with major depression when compared to healthy controls. This was especially true for erythrocyte magnesium. Furthermore, the most severely depressed patients had the highest intracellular magnesium content, showing that intracellular magnesium rate was related to the intensity of symptoms.