Promising Predictors of Adolescent Sexual Behavior Outcomes: A Systematic Review of Longitudinal Research.

This review examined research to identify longitudinal predictors of adolescent sexual behavior outcomes. These predictors hold promise as potential outcomes for teen pregnancy prevention program evaluations when measuring sexual behavior outcomes is infeasible or theoretically, methodologically, or developmentally inappropriate. We conducted a systematic review using a prespecified search strategy and processes consistent with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.

2,5-Dimethoxy-4-iodoamphetamine and altanserin induce region-specific shifts in dopamine and serotonin metabolization pathways in the rat brain.

Purpose: For understanding the neurochemical mechanism of neuropsychiatric conditions associated with cognitive deficits it is of major relevance to elucidate the influence of serotonin (5-HT) agonists and antagonists on memory function as well dopamine (DA) and 5-HT release and metabolism. In the present study, we assessed the effects of the 5-HT receptor agonist 2,5-dimethoxy-4-iodoamphetamine (DOI) and the 5-HT receptor altanserin (ALT) on object and place recognition memory and cerebral neurotransmitters and metabolites in the rat.

Methods: Rats underwent a 5-min exploration trial in an open field with two identical objects.

Synaptic vesicle release regulates pre-myelinating oligodendrocyte-axon interactions in a neuron subtype-specific manner.

Oligodendrocyte-lineage cells are central nervous system (CNS) glia that perform multiple functions including the selective myelination of some but not all axons. During myelination, synaptic vesicle release from axons promotes sheath stabilization and growth on a subset of neuron subtypes. In comparison, it is unknown if pre-myelinating oligodendrocyte process extensions selectively interact with specific neural circuits or axon subtypes, and whether the formation and stabilization of these neuron-glia interactions involves synaptic vesicle release.

5-HT and 5-HT receptor effects on recognition memory, motor/exploratory behaviors, emotionality and regional dopamine transporter binding in the rat.

Both dopamine (DA) and serotonin (5-HT) play key roles in numerous functions including motor control, stress response and learning. So far, there is scarce or conflicting evidence about the effects of 5-HT1A and 5-HT2A receptor (R) agonists and antagonists on recognition memory in the rat. This also holds for their effect on cerebral DA as well as 5-HT release.