Publications by authors named "J Hendriksen"
Article Synopsis
- A collaboration of clinicians, researchers, and family groups worked from March 2021 to March 2024 to improve tools for assessing brain involvement in Duchenne and Becker Muscular Dystrophies.
- They reached a consensus on which screening questionnaires and clinical assessments are most effective for understanding neurocognitive and neurobehavioral issues in these conditions.
- The gathered data will also help study connections between brain comorbidities, dystrophin isoforms, brain imaging, and animal models lacking these isoforms.
Article Synopsis
- Duchenne and Becker muscular dystrophy currently have no cure, but the Dutch Dystrophinopathy Database (DDD) aims to facilitate therapy development by gathering comprehensive and reusable data from affected patients.
- DDD allows for online enrollment and participation at varying levels, collecting important clinical and self-reported data while maintaining a governance structure for effective management and oversight.
- As of November 1, 2023, the database has 742 enrolled participants, enabling the identification of potential candidates for clinical studies and supporting ongoing research in the field.
Background: Glioblastoma is a highly aggressive type of brain tumor for which there is no curative treatment available. Immunotherapies have shown limited responses in unselected patients, and there is an urgent need to identify mechanisms of treatment resistance to design novel therapy strategies.
Methods: Here we investigated the phenotypic and transcriptional dynamics at single-cell resolution during nivolumab immune checkpoint treatment of glioblastoma patients.
Article Synopsis
- Childhood absence epilepsy (CAE) is a type of epilepsy in kids that usually doesn't cause long-term problems, as many kids outgrow it before becoming adults.
- Researchers studied 17 children with CAE and 15 healthy kids to compare their brain networks using special brain scans and measurements.
- They found that kids with CAE had less organized brain networks, which seemed to affect their thinking skills, showing that CAE can influence both brain structure and learning.
Introduction: Despite the increased prevalence of comorbid attention deficit hyperactivity disorder (ADHD) in children with myotonic dystrophy type 1, the effects of methylphenidate treatment on associated cognitive deficits in this population is not yet investigated.
Case: We describe a case study of an eleven-year-old male patient with myotonic dystrophy type 1 and comorbid ADHD that was treated with methylphenidate in a twice daily regime (0.60 mg/kg/day).