Calibration of a Tube Passive Sampler in Wastewater Effluent with Adjustable Volumetric Flow for the Assessment of Micropollutants with Fluctuating Concentrations.

We present a versatile flow-through tube passive sampling device (TPS), with a controllable feedwater volumetric flow, that can be calibrated against the feedwater load of organic micropollutants (OMPs). This semipassive approach has the advantage of a determinable water load feeding the sampling device. The design of the TPS allows for new sampling scenarios in closed piping while providing stable and controlled sampling conditions.

A novel augmented reality-based simulator for enhancing orthopedic surgical training.

Background: Total Hip Arthroplasty (THA) is a well-established and common orthopedic surgery. Due to the complexity involved in THA, orthopedic surgeons require rigorous training. However, the current gold standard, the tutor-guided and -evaluated apprenticeship model is time-consuming, costly, and poses risks to patients.

An almost infinite sites model.

Motivation: A main challenge in molecular evolution is to find computationally efficient mutation models with flexible assumptions that properly reflect genetic variation. The infinite sites model assumes that each mutation event occurs at a site never previously mutant, i.e.

Substrate recognition principles for the PP2A-B55 protein phosphatase.

The PP2A-B55 phosphatase regulates a plethora of signaling pathways throughout eukaryotes. How PP2A-B55 selects its substrates presents a severe knowledge gap. By integrating AlphaFold modeling with comprehensive high-resolution mutational scanning, we show that α helices in substrates bind B55 through an evolutionary conserved mechanism.

Halide Salts Alleviate TMSOK Inhibition in Suzuki-Miyaura Cross-Couplings.

The Suzuki-Miyaura cross-coupling (SMC) remains one of the most widely used transformations available to chemists. Recently, robust new conditions achieving rapid reactivity under homogeneous aprotic conditions enabled by the use of potassium trimethylsilanolate (TMSOK) as a base were reported. However, the strong inhibitory effect of TMSOK restricts the generality of such conditions.