Label free, capillary-scale blood flow mapping in vivo reveals that low-intensity focused ultrasound evokes persistent dilation in cortical microvasculature.

Non-invasive, low intensity focused ultrasound is an emerging neuromodulation technique that offers the potential for precision, personalized therapy. An increasing body of research has identified mechanosensitive ion channels that can be modulated by FUS and support acute electrical activity in neurons. However, neuromodulatory effects that persist from hours to days have also been reported.

Parkinson's families project: a UK-wide study of early onset and familial Parkinson's disease.

The Parkinson's Families Project is a UK-wide study aimed at identifying genetic variation associated with familial and early-onset Parkinson's disease (PD). We recruited individuals with a clinical diagnosis of PD and age at motor symptom onset ≤45 years and/or a family history of PD in up to third-degree relatives. Where possible, we also recruited affected and unaffected relatives.

Label free, capillary-scale blood flow mapping reveals that low intensity focused ultrasound evokes persistent dilation in cortical microvasculature.

Non-invasive, low intensity focused ultrasound (FUS) is an emerging neuromodulation technique that offers the potential for precision, personalized therapy. An increasing body of research has identified mechanosensitive ion channels that can be modulated by FUS and support acute electrical activity in neurons. However, neuromodulatory effects that persist from hours to days have also been reported.

CONSISTENT SPECTRAL CLUSTERING OF NETWORK BLOCK MODELS UNDER LOCAL DIFFERENTIAL PRIVACY.

The stochastic block model (SBM) and degree-corrected block model (DCBM) are network models often selected as the fundamental setting in which to analyze the theoretical properties of community detection methods. We consider the problem of spectral clustering of SBM and DCBM networks under a local form of edge differential privacy. Using a randomized response privacy mechanism called the edge-flip mechanism, we develop theoretical guarantees for differentially private community detection, demonstrating conditions under which this strong privacy guarantee can be upheld while achieving spectral clustering convergence rates that match the known rates without privacy.