Container Closure Integrity Testing-Method Development for Freeze-Dried Products Using Laser-Based Headspace Oxygen Analysis.

The regulatory expectations introduced by the U.S. Food and Drug Administration in 1999, ICH Q5C, the revised draft of Annex 1, Eudralex volume 4 for consultation, and the recent update of USP general chapters 1207.

Aspergilloma in sarcoidosis.

This is a case report of a 48-year-old man, followed up for nearly 30 years who initially developed sarcoidosis at the age of 18 that went into remission after 8 years of treatment. Ten years later, he developed sputum-positive tuberculosis and was cured with anti-tubercular treatment. Following this, there was progression of sarcoidosis to stage IV fibrocystic disease.

Diagnostic criteria of tuberculous sarcoidosis.

With the object to strengthen the clinical status of tuberculous sarcoidosis, we present in this article, the case records published in internationally recognized journals by specialists. From review of clinical material, we have also formulated a table that defines diagnostic criteria of tuberculous sarcoidosis.

[Traumatic pseudoaneurysm of the peroneal artery].

Traumatic arterial pseudo-aneurysm is a rare phenomenon. We describe a case of pseudoaneurysm of the peroneal artery as a late complication to an open crural fracture. Persistent or occurrence of swelling, pain, paraesthesias or sensory deficit at the fracture site should be considered symptoms of a developing arterial pseudo-aneurysm.

External fixation of distal radial fractures: 3 or 5 weeks of external fixation.

In a retrospective study we compare the functional and radiographical results of 2 groups of patients with unstable distal radial fractures treated with external fixation. In Group 1, 20 patients with 21 fractures were treated with external fixation for 3 weeks followed by a cast for 2 weeks. In Group 2, 16 patients were treated with external fixation for 5 weeks.