Publications by authors named "J Healey"
Risk of bleeding with the concurrent use of amiodarone and DOACs: A systematic review and meta-analysis.
Eur Heart J Cardiovasc Pharmacother
December 2024
Background And Aims: Amiodarone is frequently prescribed alongside direct oral anticoagulants (DOACs) in atrial fibrillation (AF). There are concerns regarding drug-drug interactions (DDIs) between amiodarone and DOACs. The literature is conflicting on the clinical implications of this DDI, hence we conducted a meta-analysis to compare bleeding risk among patients receiving DOACs, with and without concurrent amiodarone.
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- The LightFix Trial aimed to assess the effectiveness of the IlluminOss System (IS) in treating impending and completed pathological fractures of the humerus over one year.
- A study with 81 patients showed significant decreases in pain and increases in upper limb function after treatment, with notable improvements in pain scores and functional metrics throughout the year.
- While the IS provided benefits, it had a device fracture rate of 15%, suggesting caution when used alone for completed fractures.
Objectives: Atrial fibrillation is the most common complication of cardiac surgery and occurs frequently in patients without a history of the arrhythmia. We conducted a systematic review and meta-analysis of randomized controlled trials to assess whether prophylactic ablation during cardiac surgery in patients without a history of atrial fibrillation prevents atrial fibrillation.
Methods: We searched CENTRAL, MEDLINE and Embase from inception to August 2024.
Aims: The left atrial appendage (LAA) produces natriuretic peptides and its removal or occlusion might increase the risk of heart failure (HF). We aimed to investigate the incidence of HF after LAA occlusion or removal (LAAO) in the Left Atrial Appendage Occlusion Study (LAAOS III).
Methods And Results: Patients (n = 4811) with atrial fibrillation (AF) and a CHADS-VASc score ≥2, who were having cardiac surgery for another indication, were randomized to undergo surgical LAAO or not.
Background: Clinically important perioperative atrial fibrillation (POAF) is a common cardiac complication after noncardiac surgery. Little is known about how patients with POAF are managed acutely and whether practices have changed over time.
Methods: We conducted an observational substudy of patients who had POAF, were at elevated cardiovascular risk, and were enrolled in the PeriOperative Ischemic Evaluation (POISE)-1, 2 and 3 trials between 2002 and 2021.