Publications by authors named "J Haug"
Since the seminal report by Adachi and co-workers in 2012, there has been a veritable explosion of interest in the design of thermally activated delayed fluorescence (TADF) compounds, particularly as emitters for organic light-emitting diodes (OLEDs). With rapid advancements and innovation in materials design, the efficiencies of TADF OLEDs for each of the primary color points as well as for white devices now rival those of state-of-the-art phosphorescent emitters. Beyond electroluminescent devices, TADF compounds have also found increasing utility and applications in numerous related fields, from photocatalysis, to sensing, to imaging and beyond.
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- The study investigates the role of Frizzled5 (Fzd5), a receptor in the Wnt signaling pathway, in maintaining the health and function of intestinal epithelial cells.
- Deleting Fzd5 in specific intestinal stem cells impairs their ability to renew and generate new cells, affecting different aspects of epithelial structure but not overall integrity.
- Comprehensive analysis reveals that Fzd5 regulates gene expression by influencing chromatin accessibility in stem and progenitor cells, highlighting its crucial function in intestinal epithelial plasticity.
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- Neurocristopathies like CHARGE syndrome are linked to abnormal development of neural crest cells, mainly due to genetic mutations in the CHD7 gene, which is crucial for chromatin remodeling.
- Researchers used epigenomic profiling of neural crest cells in chick and human models to identify enhancers that control the expression of CHD7.
- The study established connections between transcription factors and enhancers specific to neural crest cells, highlighting the gene's role in a broader regulatory network and providing insights for better understanding CHARGE syndrome cases.
Ribosomal RNA (rRNA) genes exist in multiple copies arranged in tandem arrays known as ribosomal DNA (rDNA). The total number of gene copies is variable, and the mechanisms buffering this copy number variation remain unresolved. We surveyed the number, distribution, and activity of rDNA arrays at the level of individual chromosomes across multiple human and primate genomes.
View Article and Find Full Text PDFWe present a mechanically sheared image acquisition format for upright and open-top light-sheet microscopes that automatically places data in its proper spatial context. This approach, which reduces computational post-processing and eliminates unnecessary interpolation or duplication of the data, is demonstrated on an upright variant of axially swept light-sheet microscopy (ASLM) that achieves a field of view, measuring 774 × 435 microns, that is 3.2-fold larger than previous models and a raw and isotropic resolution of ∼460 nm.
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