Publications by authors named "J Hasenkamp"
Article Synopsis
- Allogeneic stem cell transplantation (alloSCT) is an effective treatment to cure patients with relapsed/refractory (r/r) aggressive lymphomas, particularly focusing on peripheral T-cell lymphoma (PTCL) and diffuse large B-cell lymphoma (DLBCL).
- The study found that patients with PTCL had significantly better outcomes compared to those with DLBCL in terms of 5-year progression-free survival (PFS) and overall survival (OS), especially after the first 100 days post-transplant.
- Despite similar rates of non-relapse mortality, DLBCL patients faced higher rates of relapse mortality, and the presence of extensive chronic graft-versus-host disease (GvHD) negatively impacted outcomes for both
Improved long-term survival rates after allogeneic hematopoietic cell transplantation (alloHCT) make family planning for young adult cancer survivors an important topic. However, treatment-related infertility risk poses challenges. To assess pregnancy and birth rates in a contemporary cohort, we conducted a national multicenter study using data from the German Transplant Registry, focusing on adult women aged 18 to 40 years who underwent alloHCT between 2003 and 2018.
View Article and Find Full Text PDFATOS is a prospective observational study evaluating the outcome of patients receiving anti-human T-lymphocyte immunoglobulin (ATLG) in unrelated donor transplantation. Primary endpoint was severe GvHD and relapse-free survival (SGRFS). GvHD prophylaxis consisted of ATLG and CSA/ MTX or MMF.
View Article and Find Full Text PDFBackground: Bacterial infection ranks amongst the most common causes of morbidity and mortality in patients undergoing allogeneic haematopoietic stem cell transplantation (alloHSCT). Although ciprofloxacin (CIP) prophylaxis is recommended, information on serum levels and clinical course is lacking.
Aim: To investigate relationships between CIP level and failure of prophylaxis, particularly in terms of whether different pharmacokinetic (PK) indices [area under the concentration-time curve (AUC) vs single time samples] correlate differently with the outcome.