Publications by authors named "J Hartigh den"
Background: Male breast cancer (MBC) is a rare disease, accounting for 1% of all breast cancers diagnosed in the United States. The rarity of MBC has limited the development of treatment algorithms specific to men. Thus, the standard of care has been mastectomy.
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- Breast cancer (BC) is a major health concern, especially in women with schizophrenia, who experience higher mortality rates; the project aimed to assess the incidence of BC in this group and compare outcomes based on antipsychotic medication use prior to diagnosis.
- Utilizing the TriNetX database, the study examined data from over 1.3 million women with schizophrenia from 2011 to 2023, finding that breast cancer incidence was consistent over the years but peaked in 2017; non-Hispanic women had higher diagnosis rates compared to Hispanic women.
- Results indicated that women not on antipsychotics prior to BC diagnosis had significantly better 5-year survival rates (72% vs. 60%) and lower risks of local
Recent Advances in Breast Cancer Diagnosis, Treatment, Psychology, Management, and Reconstruction.
Medicina (Kaunas)
January 2023
Breast cancer is the second most common cancer in women after skin cancer [...
View Article and Find Full Text PDFAnemia of inflammation, as found in many chronic disease states, is common among persons with diabetic foot infections but is typically mild and self-limited. Herein we present four cases of patients with foot infections accompanied by severe anemia (nadir hemoglobin <8 gm/dL and resulting in transfusion of 4 + units of blood) as well as significant weight loss (30 + pounds), hyponatremia (<135 mmol/L), hypoalbuminemia (nadir <2 gm/dL), uremia and other metabolic derangements.
View Article and Find Full Text PDFBackground: Multiple Myeloma (MM) is a hematological malignancy with genomic heterogeneity and poor survival outcome. Apart from the central role of genetic lesions, epigenetic anomalies have been identified as drivers in the development of the disease.
Methods: Alterations in the DNA methylome were mapped in 52 newly diagnosed MM (NDMM) patients of six molecular subgroups and matched with loci-specific chromatin marks to define their impact on gene expression.