Publications by authors named "J Haroche"
Lin et al. report the long-term follow-up of a phase II trial involving 95 adult patients with Langerhans cell histiocytosis (LCH), investigating the combination of methotrexate and cytarabine (MA). After a median follow-up of 6.
View Article and Find Full Text PDFObjectives: Lymphadenopathy is a classical manifestation of systemic lupus erythematosus (SLE) flare, occurring in approximately half of patients during the course of the disease. Lymphadenopathy in SLE is frequently associated with fever. Microbial infection may play a role in SLE onset and flares.
View Article and Find Full Text PDFArticle Synopsis
- Indeterminate dendritic cell histiocytosis (IDCH) is a rare condition marked by a buildup of specific histiocytes, with particular immunophenotypic features and clinical presentations, mostly in older adults.
- The study analyzed 43 cases, showing that many patients had skin or lymph node involvement, and a significant number had related blood cancers or other histiocytic diseases.
- Genetic analyses identified common mutations (like KRAS and BRAF) and unique gene fusions, helping to clarify IDCH's molecular profile and its potential impact on diagnosis and treatment strategies.