Maternal Western Diet Programmes Bile Acid Dysregulation and Hepatic Fibrosis in Fetal and Juvenile Macaques.

Background And Aims: Maternal obesity increases the risk of the paediatric form of metabolic dysfunction-associated steatotic liver disease (MASLD), affecting up to 30% of youth, but the developmental origins remain poorly understood.

Methods: Using a Japanese macaque model, we investigated the impact of maternal Western-style diet (mWSD) or chow diet followed by postweaning WSD (pwWSD) or chow diet focusing on bile acid (BA) homeostasis and hepatic fibrosis in livers from third-trimester fetuses and 3-year-old juvenile offspring.

Results: Juveniles exposed to mWSD had increased hepatic collagen I/III content and stellate cell activation in portal regions.

Genomic interrogation of commercial infant probiotic products for label accuracy.

Objective: To evaluate the label accuracy of commercial infant probiotic products and identify potential microbial contamination.

Methods: DNA was extracted from seventeen infant probiotic products purchased from a large online vendor. Samples underwent 16S ribosomal RNA gene sequencing, QIIME analysis, and bacterial taxonomic classification.

Cross-Point Ferroelectric HfZrO Capacitors for Remanent Polarization-Driven In-Memory Computing.

Ferroelectric HfZrO (HZO) capacitors have been extensively explored for in-memory computing (IMC) applications due to their nonvolatility and back-end-of-line (BEOL) compatible process. Several IMC approaches using resistance and capacitance states in ferroelectric HZO have been proposed for vector-matrix multiplication (VMM), but previous approaches suffer from limited accuracy and reliability. In this work, we propose a promising approach centered on the remanent polarization (P) switching of binary ferroelectric HZO capacitor synapses.

Does Body Postural Configuration Affect Upper Limb Performance During Point-to-Point Hand Movements?

Adopting a postural configuration may be regarded as preparation for the performance of an upcoming movement. However, it is unclear how different postural configurations affect motor performance. The aim of the current study was to examine how body posture - sitting versus standing - influences fast and accurate planar point-to-point hand movements.