Establishing the UHB doctor wellbeing group as a model for sustainable change in improving resident doctor wellbeing.

Significant wellbeing concerns have been reported nationally among resident doctors. A peer-led survey at University Hospitals Birmingham NHS Foundation Trust revealed high burnout risk and dissatisfaction. The Doctor Wellbeing Group (DWG) was established to address these multifaceted concerns by supporting resident doctors to run quality improvement projects to improve working conditions, with consultant supervision and regular reports to stakeholders.

Nitazene opioids and the heart: Identification of a cardiac ion channel target for illicit nitazene opioids.

The growing use of nitazene synthetic opioids heralds a new phase of the opioid crisis. However, limited information exists on the toxic effects of these drugs, aside from a propensity for respiratory depression. With restricted research availability of nitazenes, we used machine-learning-based tools to evaluate five nitazene compounds' interaction potential with the hERG potassium channel, a key drug antitarget in the heart.

Enhancing wellbeing in medical practice: Exploring interventions and effectiveness for improving the work lives of resident (junior) doctors: A systematic review and narrative synthesis.

Introduction: Globally, resident doctors face challenges like long work hours, critical decision-making stress, and exposure to death and distress, prompting concern for their wellbeing. This study addresses the need for interventions to improve their working conditions, vital for enhancing quality of life, patient care and retaining a skilled workforce.

Methods: Following PRISMA guidelines, a systematic literature review until 3 January 2024 explored interventions for resident Ddoctors pre- and post-COVID-19.

Modulation of Spontaneous Action Potential Rate by Inositol Trisphosphate in Myocytes from the Rabbit Atrioventricular Node.

The atrioventricular node (AVN) is a key component of the cardiac conduction system and takes over pacemaking of the ventricles if the sinoatrial node fails. IP (inositol 1,4,5 phosphate) can modulate excitability of myocytes from other regions of the heart, but it is not known whether IP receptor (IP-R) activation modulates AVN cell pacemaking. Consequently, this study investigated effects of IP on spontaneous action potentials (APs) from AVN cells isolated from rabbit hearts.