Publications by authors named "J Halonen"
Single-nuclei RNA sequencing remains a challenge for many human tissues, as incomplete removal of background signal masks cell-type-specific signals and interferes with downstream analyses. Here, we present Quality Clustering (QClus), a droplet filtering algorithm targeted toward challenging samples. QClus uses additional metrics, such as cell-type-specific marker gene expression, to cluster nuclei and filter empty and highly contaminated droplets, providing reliable filtering of samples with varying number of nuclei and contamination levels.
View Article and Find Full Text PDFActive commuting can be beneficial for health. We examined whether active commuting by walking or cycling was associated with a lower risk of sickness absence in a Finnish public sector cohort of 28 485 employees. We used negative binomial regression to test associations of weekly active commuting in kilometers (no, low, moderate, and high dose) with all-cause sickness absence.
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- The quality of a neighborhood significantly impacts residents' overall quality of life and health, especially as urbanization increases.
- A study analyzed survey data from over 2,000 adults in Finland, finding that 80% viewed their neighborhoods as liveable, with key factors being socioeconomic status, urban location, green views, and satisfaction with safety and green spaces.
- The research emphasizes the importance of involving residents in neighborhood decision-making to enhance perceptions of liveability, with only minor effects seen from residents being more settled in their neighborhoods.
Green spaces may serve as population level interventions encouraging active travel. We examined the associations between exposure to useable green space (CORINE Land Cover categories) and physical activity during active travel (GPS and accelerometer) among late middle-aged participants from the Finnish Retirement and Aging study (n = 102). Greater proportion of useable green space was associated with higher physical activity during active travel on days off (+11 min/day per 1 SD increase in exposure) and on retirement days (+12 min/day), but not on workdays.
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- The study aims to investigate how survey data can be used to identify factors that influence people's choices of transportation for their daily commutes, specifically among public sector employees in Finland.
- Researchers used data from a large survey involving over 42,000 employees, focusing on those commuting 5 km or less, to create a prediction model for commuting behaviors in various weather conditions.
- Results showed that factors such as commute length, physical activity levels, BMI, and demographics like sex and age significantly predict whether individuals choose active transport (bike or walking) or passive transport (car) in summer and winter.