Long-Term Efficacy and Safety of Denosumab: Insights beyond 10 Years of Use.

Osteoporosis management in post-menopausal women focuses on fracture prevention, with denosumab as a key therapeutic option. Despite its proven efficacy in reducing fracture risk and increasing bone mineral density (BMD) over 10 years, its long-term impact remains uncertain. We evaluated the literature on its efficacy and safety beyond the initial decade.

Role of PI3K/AKT signaling pathway during capacitation.

Spermatozoa must undergo a complex maturation process within the female genital tract known as capacitation. This process entails the phosphorylation or dephosphorylation of various proteins, and multiple signaling pathways are recognized to play a role. The present study aims to identify alterations in the expression of proteins related to the phosphatidylinositol-3 kinase (PI3K)/protein kinase B (AKT) signaling pathway and assess sperm functions during capacitation.

Validation of the 2022 ACR/EULAR classification criteria for giant cell arteritis in Koran patients with giant cell arteritis.

Objectives: We applied the 2022 American College of Rheumatology (ACR)/European Alliance of Association for Rheumatology (EULAR) criteria to Korean patients previously diagnosed with giant cell arteritis (GCA) according to the 1990 ACR criteria and validated its clinical efficiency.

Methods: Nine patients with GCA were included in this study. The proportion of patients meeting each item of the 1990 ACR criteria and the 2022 ACR/EULAR criteria were assessed.

Ultrafast MRI for Pediatric Brain Assessment in Routine Clinical Practice.

Objective: To assess the feasibility of ultrafast brain magnetic resonance imaging (MRI) in pediatric patients.

Materials And Methods: We retrospectively reviewed 194 pediatric patients aged 0 to 19 years (median 10.2 years) who underwent both ultrafast and conventional brain MRI between May 2019 and August 2020.

Unveiling the Competition among Surface Damping Pathways in Single Gold Nanorods Immobilized on Graphene Using Amine Derivatives as Adsorbates.

Understanding plasmon damping in gold nanorods (AuNRs) is crucial for optimizing their use in photochemical processes and biosensing. This study used dark-field microscopy and spectroscopy to explore plasmon damping in single AuNRs on graphene monolayers (AuNR@GL) with pyridine derivatives as adsorbates. The Au-graphene heterostructure caused a Fermi-level downshift, making graphene a dominant electron acceptor.