Publications by authors named "J HOELZL"
Article Synopsis
- The study examines how variations in tumor microenvironments (TMEs) affect cancer progression by analyzing 52 head and neck squamous cell carcinomas.
- It identifies macrophage polarity—determined by CS expression—as a significant factor for prognosis, rather than traditional M1 and M2 classifications.
- The findings indicate that TMEs create organized networks of pro- and antitumor responses, emphasizing that CS macrophage polarity could simplify understanding complex cancer behaviors across different types of tumors.
Aim: Appendiceal neoplasms are rare subtypes of colorectal tumours that mainly affect younger patients some 20 years earlier than other colon tumours. The aim of this study was to gain more insight into the histological subtypes of this rare disease and include cases previously excluded, such as mucinous neoplasia.
Method: The cohort study included 1097 patients from the Munich Cancer Registry (MCR) diagnosed between 1998 and 2020.
Cellular analyses are increasingly used to diagnose diseases at point-of-care and global healthcare settings. Some analyses are simple as they rely on chromogenic stains (blood counts, malaria) but others often require higher multiplexing to define and quantitate cell populations (cancer diagnosis, immunoprofiling). Simplifying the latter with inexpensive solutions represents a current bottleneck in designing start-end pipelines.
View Article and Find Full Text PDFThe role of microvascular fluid shifts in the adaptation to hypobaric hypoxia and its contribution to the pathophysiology of AMS (acute mountain sickness) is unresolved. In a systematic prospective study, we investigated the effects of hypobaric hypoxia and physical exercise alone, and in combination, on microvascular fluid exchange and related factors. We used computer-assisted VCP (venous congestion plethysmography) on the calves of ten altitude-acclimatized volunteers.
View Article and Find Full Text PDF