Publications by authors named "J HEROLD"
Article Synopsis
- Genome-wide association studies (GWAS) have discovered many genetic loci related to diseases, but the influence of age on these genetic effects has been overlooked, and small sample sizes make it hard to study changes over time.
- The study proposes a two-step method that first uses cross-sectional data to identify genetic-by-age interactions and then tests these findings in separate longitudinal data, analyzing traits in a large UK Biobank sample.
- The results show that specific genetic interactions with age are associated with changes in traits like obesity and pulse pressure, revealing the importance of understanding how genetics and age interact to affect health over time.
Age-related macular degeneration (AMD) is a leading cause of blindness with $344 billion dollars global costs. In 2016, the International Age-related Macular Degeneration Genomics Consortium devised genomic data on ∼50,000 individuals (IAMDGC 1.0) and identified 52 variants across 34 loci associated with advanced AMD in European ancestry.
View Article and Find Full Text PDFUnderstanding the genetics of kidney function decline, or trait change in general, is hampered by scarce longitudinal data for GWAS (longGWAS) and uncertainty about how to analyze such data. We use longitudinal UK Biobank data for creatinine-based estimated glomerular filtration rate from 348,275 individuals to search for genetic variants associated with eGFR-decline. This search was performed both among 595 variants previously associated with eGFR in cross-sectional GWAS and genome-wide.
View Article and Find Full Text PDFPurpose: Since winter 2022, invasive GAS (iGAS) infections have re-emerged in Europe, causing severe diseases in children and adults. We aimed to examine whether this reported post-pandemic increase was associated with an increased disease severity and/or a shift in clinical disease phenotypes.
Methods: We performed detailed clinical phenotyping of patients hospitalized with iGAS infections at a 1410-bed tertiary German Medical Center from 01/2015 to 09/2023.
PD-1 blockade does not improve efficacy of EpCAM-directed CAR T-cell in lung cancer brain metastasis.
Cancer Immunol Immunother
October 2024
Background: Lung cancer brain metastasis has a devastating prognosis, necessitating innovative treatment strategies. While chimeric antigen receptor (CAR) T-cell show promise in hematologic malignancies, their efficacy in solid tumors, including brain metastasis, is limited by the immunosuppressive tumor environment. The PD-L1/PD-1 pathway inhibits CAR T-cell activity in the tumor microenvironment, presenting a potential target to enhance therapeutic efficacy.
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