Publications by authors named "J H van de Berge"
Objective: To describe clinical features, treatment strategies and visual acuity changes of eyes with uveitic macular oedema (UMO) in ocular tuberculosis (OTB) patients from a non-TB-endemic country.
Methods: This retrospective study was conducted using a 10-year period registry of OTB patients diagnosed in Erasmus MC, Rotterdam. Longitudinal analysis of visual acuity trajectory in eyes with and without UMO was performed using linear mixed effect model.
The objective of this study was to explore barriers and facilitators to utilising a range of food assistance resources as reported by parents living with or at risk for food insecurity (FI), as well as parents' recommendations for improving utilisation of these resources. Qualitative data from semi-structured interviews about parents' perspectives on interventions to address FI were analysed using a hybrid deductive/inductive thematic approach. Parents were drawn from the larger longitudinal cohort study ( = 1,307), which was recruited from primary care clinics in Minnesota.
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- This study investigated serum levels and activity of interferon (IFN) in patients with sarcoidosis and tuberculosis (TB), focusing on those with uveitis, to understand IFN's role in these diseases.
- Serum samples from patients in Indonesia (TB) and the Netherlands (sarcoidosis) were analyzed using specific assays to measure IFN types and activity, as well as the presence of autoantibodies against IFN.
- The results showed significantly higher levels of IFNα2 and IFNγ in sarcoidosis patients compared to TB patients, particularly in those with uveitis, suggesting that IFN may be a useful marker for distinguishing between these two similar conditions.
Article Synopsis
- Sarcoidosis and tuberculosis (TB) are similar granulomatous diseases that can cause uveitis, prompting a study of inflammation-related proteins in serum from patients in the Netherlands (sarcoidosis) and Indonesia (TB).
- Researchers found 192 proteins unique to sarcoidosis and 102 unique to active pulmonary TB when compared to healthy controls, but noted overlapping immune pathways in both diseases.
- A specific B-lymphocyte activation signature linked to sarcoidosis was identified, distinguishing it from TB, indicating that B-cell signaling differences are a crucial immunological factor between the two conditions.