Halogen bonding BODIPY-appended pillar[5]arene for the optical sensing of dicarboxylates and a chemical warfare agent simulant.

A pillar[5]arene host, functionalised with halogen bonding (XB) recognition sites and BODIPY fluorophores, demonstrates strong binding and optical sensing of environmentally relevant dicarboxylates and a chemical warfare agent simulant, in organic and competitive aqueous-organic media - enabled by the unprecedented combination of fluorophore-conjugated XB interactions with the hydrophobic pillar[5]arene host cavity.

Gut commensals require Peyer's patches to induce protective systemic IgA responses.

Gut educated IgA secreting plasma cells that disseminate beyond the mucosa and into systemic tissues have been described as providing beneficial effects from disease in several contexts. Several bacteria have been implicated in the induction of systemic IgA, however the mechanisms that result in differential levels of induction by each bacterial species are still unknown. Here we show, the commensal bacteria, (), is an efficient inducer of systemic IgA responses.

Biomaterial engineering strategies for B cell immunity modulations.

B cell immunity has a penetrating effect on human health and diseases. Therapeutics aiming to modulate B cell immunity have achieved remarkable success in combating infections, autoimmunity, and malignancies. However, current treatments still face significant limitations in generating effective long-lasting therapeutic B cell responses for many conditions.

Unveiling cytokine charge disparity as a potential mechanism for immune regulation.

Cytokines are small signaling proteins that regulate the immune responses to infection and tissue damage. Surface charges of cytokines determine their in vivo fate in immune regulation, e.g.